Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip
نویسندگان
چکیده
منابع مشابه
Botulinum Neurotoxins
Botulism is a neuroparalytic disease caused by neurotoxin produced from the bacterium Clostridium botulinum. The botulinum neurotoxins (BoNTs) are among the most potent known biological toxins and have an estimated human median lethal dose (LD50) in the nanogram/kilogram range. Botulinum toxins have historically been employed as biological weapons (BW) through state-sponsored programs in Japan,...
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Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors targeting common steps of their intoxication process. Recently, EGA was shown to inhibit the action of bacterial toxins and viruses exhibiting a pH-dependent translocation step in mammalian cells, by interfering with their entr...
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Christopher Lieu, MD William J. Janssen, MD Sanjay Saint, MD, MPH Gurpreet Dhaliwal, MD 1 Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado. 2 Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado. 3 Ann Arbor Veterans Affairs Health Services Research and Development Center of Excellence, Ann Arbor, Michigan. 4 Patient Safety...
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Rheumatic heart disease (RHD) remains one of the largest preventable burdens of disease in the world. It is perceived as a disease of childhood, acquired by streptococcal throat infection of the tonsillo-pharynx, leading to an inflammatory reaction that involves many organs, including the heart. However, cases in children of 5 to 14 years of age are likely to represent only 15% to 20% of all ca...
متن کاملBotulinum Neurotoxins and Botulism: A Novel Therapeutic Approach
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with supportive and symptomatic management. The antibody works extracellularly, probably by blocking the binding of receptor binding (R) domain to the...
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ژورنال
عنوان ژورنال: Toxins
سال: 2018
ISSN: 2072-6651
DOI: 10.3390/toxins10050190